HIV RESERVOIRS
THE BRAIN
The blood-brain barrier prevents ARVs from easily accessing the tissues.The brain provides a protected reservoir for HIV,where the virus developes brain mutation that allow it to become more virulent against the central nervous system.
BONE MARROW
HIV can hide inside multipotent hematopoetic progenter cells in the bone marrow,presenting a challenge for efforts at eradication.HPCs are a type of stem cells that gives rise to multiple type of blood cells.
THE CENTRAL NERVOUS SYSTEM
CNS can potentially act as a viral reservoir of HIV. However, the majority of this studies were performed in absence of combination of antiretroviral therapy.CNS cells have unique molecular mechanism to surpress viral replication and induce latency which include increased expression of dominant negative transcription factors and suppressive epigenetic factors.There is also evidence of continued inflammation in patients lacking a CNS viral load, suggesting the production and activity of viral neurotoxins.
THE LUNGS AND KIDNEY
In lungs HIV is recovered from the alveolar lymphocytes indicating that the virus is carried to the lungs by the cells as they migrate from the blood in response to opportunistic infections. In kidney, the combination of productive and independent HIV infection in a localized manner within the renal tissue suggest the existence of a renal viral reservoir.
The blood-brain barrier prevents ARVs from easily accessing the tissues.The brain provides a protected reservoir for HIV,where the virus developes brain mutation that allow it to become more virulent against the central nervous system.
BONE MARROW
HIV can hide inside multipotent hematopoetic progenter cells in the bone marrow,presenting a challenge for efforts at eradication.HPCs are a type of stem cells that gives rise to multiple type of blood cells.
THE CENTRAL NERVOUS SYSTEM
CNS can potentially act as a viral reservoir of HIV. However, the majority of this studies were performed in absence of combination of antiretroviral therapy.CNS cells have unique molecular mechanism to surpress viral replication and induce latency which include increased expression of dominant negative transcription factors and suppressive epigenetic factors.There is also evidence of continued inflammation in patients lacking a CNS viral load, suggesting the production and activity of viral neurotoxins.
THE LUNGS AND KIDNEY
In lungs HIV is recovered from the alveolar lymphocytes indicating that the virus is carried to the lungs by the cells as they migrate from the blood in response to opportunistic infections. In kidney, the combination of productive and independent HIV infection in a localized manner within the renal tissue suggest the existence of a renal viral reservoir.
BETH
The human body is everything that makes us unique and it the most amazing thing that GOD gave us.
ReplyDeleteIn the brain it provide a protected reservoir for HIV where the virus can developes brain mutation that allowe it to become more in the central nervous systems...... By Rahma
ReplyDeleteThe brain helps the body to control any infections, by using antiviral drugs the immune system stays strong and able to fight against HIV virus where by the brain acts as a control center for the body .
ReplyDeleteHiv hidding from the borm marrow making medicine very hard to fight the disease
ReplyDeleteThe brain helps to control hiv infection because the preventive measures are in the mind but presence of ARV'S helps to boost the body in fighting the virus
ReplyDelete